Written by: Soo Xuan Jay, Pharmacy Graduate (PRP)
Last updated: 8 April 2026
Quick answer — what is the best painkiller for toothache?
Ibuprofen is usually the best painkiller for toothache because it reduces inflammation, which is the main cause of dental pain. Panadol (paracetamol) can help with pain but is often less effective on its own. For stronger pain, both may be used together short-term if suitable.
How to relieve toothache fast
- Take ibuprofen if suitable
- Add Panadol for stronger relief if needed
- Avoid very hot or cold food
- Rinse with warm salt water
- See a dentist as soon as possible
Best painkiller for toothache — quick comparison
| Painkiller | Best for | When to use |
| Ibuprofen | Inflammation and swelling | First choice for toothache |
| Panadol (paracetamol) | Pain relief | If ibuprofen is not suitable |
| Combination | Stronger pain | Short-term use if needed |
In short: use ibuprofen if inflammation is present, Panadol if ibuprofen is not suitable, and combine both short-term if pain is severe.
What should you take for toothache?
In practice, toothache is often caused by inflammation or infection, so the choice of painkiller matters.
Do you need antibiotics for toothache?
In practice, antibiotics are not always needed for toothache. Most cases require dental treatment rather than medication alone.
Antibiotics are only used when there is clear infection with swelling or systemic symptoms.
Step 1: Start with ibuprofen if suitable
Ibuprofen is usually more effective because it reduces inflammation in the affected tooth and surrounding tissues.
Ibuprofen should usually be taken after food to reduce stomach irritation.
Step 2: Reassess your symptoms
If the pain does not improve, consider whether there is swelling, infection, or worsening symptoms.
- Swelling of gums or face: suggests inflammation or infection
- Pain when biting: possible dental damage or abscess
- Throbbing pain: commonly associated with infection
- Sensitivity to hot or cold: nerve involvement
These signs help determine whether simple pain relief is enough or if dental treatment is needed.
Step 3: Add Panadol if needed
Panadol can be added for additional pain relief, as it works differently from ibuprofen.
Step 4: Avoid relying only on painkillers
Painkillers do not treat the underlying dental problem. Relief is usually temporary.
In practice, toothache may worsen at night due to increased blood flow and pressure in the affected area.
Step 5: See a dentist as soon as possible
Pain relief from medication is temporary and does not treat the underlying cause.
Persistent toothache usually requires dental treatment such as filling, root canal, or extraction.
How to take painkillers for toothache
In practice, correct dosing is just as important as choosing the right medication.
- Ibuprofen: 200–400 mg every 6–8 hours (after food)
- Panadol: 500–1000 mg every 4–6 hours
Avoid exceeding the maximum daily dose and avoid taking doses too close together.
Why ibuprofen works better for toothache
Toothache is commonly caused by inflammation in the tooth or surrounding tissue. Ibuprofen reduces inflammation, which directly addresses the cause of pain.
Panadol reduces pain signals but does not reduce inflammation, which is why it may be less effective on its own.
When Panadol may still be used
- If you cannot take ibuprofen
- If you have stomach issues
- If you need additional pain relief
When painkillers are not enough
In practice, toothache often indicates an underlying dental problem such as infection or decay.
If pain persists despite medication, dental treatment is required rather than increasing medication.
When toothache becomes urgent
- Swelling of the face or jaw
- Fever or feeling unwell
- Severe or worsening pain
- Difficulty swallowing or breathing
When to be concerned
- Swelling of the face or jaw
- Fever or feeling unwell
- Difficulty opening the mouth
- Pain lasting more than 1–2 days
Key takeaway
Ibuprofen is usually the best painkiller for toothache because it reduces inflammation. Panadol may be used if ibuprofen is not suitable or as additional relief. Persistent toothache should always be assessed by a dentist.
FAQ
Is ibuprofen or Panadol better for toothache?
Ibuprofen is usually better because it reduces inflammation, while Panadol mainly relieves pain.
What is the fastest pain relief for toothache?
Ibuprofen usually provides faster relief because it reduces inflammation.
Can I take Panadol for toothache?
Yes, but it may be less effective on its own compared to ibuprofen.
Can I take Panadol and ibuprofen together for toothache?
Yes, for short-term use if suitable, as they work differently.
Why does toothache keep coming back?
It is usually caused by an underlying dental issue that requires treatment.
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Disclaimer
This content is for educational purposes only and does not replace professional medical advice. Always consult a doctor or dentist for personalised guidance.